Abstract #1040
Isotropic 1 H and Hyperpolarized 129 Xe Gas- and Dissolved-Phase MRI for Longitudinal Evaluation of Lung Cancer
Rohan S Virgincar 1 , Scott H Robertson 2 , Simone Degan 3,4 , Matthew S Freeman 2 , Mu He 5 , and Bastiaan Driehuys 4
1
Biomedical Engineering, Duke University,
Durham, North Carolina, United States,
2
Medical
Physics Graduate Program, Duke University, Durham, North
Carolina, United States,
3
Center
for Molecular and Biomolecular Imaging, Duke University,
Durham, North Carolina, United States,
4
Radiology,
Duke University Medical Center, Durham, North Carolina,
United States,
5
Electrical
and Computer Engineering, Duke University, Durham, North
Carolina, United States
We present high-resolution and high-SNR isotropic
129
Xe
gas- and dissolved-phase MR imaging in mice to study
lung cancer progression longitudinally. This was enabled
by an optimized 3D radial image acquisition with 20%
129
Xe
polarization. Animals were scanned up to 3 times before
being sacrificed for histology.
129
Xe
images showed significant impairment of ventilation and
gas-exchange 4-6 weeks post tumor instillation that
closely matched tumor distribution on
1
H
MRI. This non-invasive imaging capability is now well
suited to study the progression of a variety of lung
disorders and therapy response.
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