Abstract #1040
Isotropic 1 H and Hyperpolarized 129 Xe Gas- and Dissolved-Phase MRI for Longitudinal Evaluation of Lung Cancer
Rohan S Virgincar 1 , Scott H Robertson 2 , Simone Degan 3,4 , Matthew S Freeman 2 , Mu He 5 , and Bastiaan Driehuys 4
1
Biomedical Engineering, Duke University,
Durham, North Carolina, United States,
2
Medical
Physics Graduate Program, Duke University, Durham, North
Carolina, United States,
3
Center
for Molecular and Biomolecular Imaging, Duke University,
Durham, North Carolina, United States,
4
Radiology,
Duke University Medical Center, Durham, North Carolina,
United States,
5
Electrical
and Computer Engineering, Duke University, Durham, North
Carolina, United States
We present high-resolution and high-SNR isotropic
129
Xe
gas- and dissolved-phase MR imaging in mice to study
lung cancer progression longitudinally. This was enabled
by an optimized 3D radial image acquisition with 20%
129
Xe
polarization. Animals were scanned up to 3 times before
being sacrificed for histology.
129
Xe
images showed significant impairment of ventilation and
gas-exchange 4-6 weeks post tumor instillation that
closely matched tumor distribution on
1
H
MRI. This non-invasive imaging capability is now well
suited to study the progression of a variety of lung
disorders and therapy response.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
