Abstract #1049
Correlation between MRI-derived Quantitative Biomarkers and Circulating Tumor Cells in Prostate Cancer
Radka Stoyanova 1 , Sakhi Abraham 1 , Adrian Breto 1 , Zheng Ao 2 , Anthony Williams 2 , Jorge Torres-Munoz 2 , Ram Datar 2 , Richard Cote 2 , Yosef Zeidan 1 , Adrian Ishkanian 1 , Matthew Abramowitz 1 , and Alan Pollack 1
1
Radiation Oncology, University of Miami,
Miami, Florida, United States,
2
Pathology,
University of Miami, Miami, Florida, United States
Circulating tumor cells (CTC) are rare malignant cells
found in the peripheral blood of patients with a wide
range of solid tumors. In this study we investigated the
correlation of CTC counts with the prostate tumor
volume, tissue perfusion and diffusion properties,
estimated from multiparametric (MP)-MRI. These imaging
biomarkers were related to CTC counts in patients
enrolled in a contemporary randomized clinical trial for
definitive radiotherapy of prostate cancer. This is, to
our knowledge, the first study comparing CTC counts with
in vivo measurements of tumor volume, perfusion and
diffusion.
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