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Abstract #1049

Correlation between MRI-derived Quantitative Biomarkers and Circulating Tumor Cells in Prostate Cancer

Radka Stoyanova 1 , Sakhi Abraham 1 , Adrian Breto 1 , Zheng Ao 2 , Anthony Williams 2 , Jorge Torres-Munoz 2 , Ram Datar 2 , Richard Cote 2 , Yosef Zeidan 1 , Adrian Ishkanian 1 , Matthew Abramowitz 1 , and Alan Pollack 1

1 Radiation Oncology, University of Miami, Miami, Florida, United States, 2 Pathology, University of Miami, Miami, Florida, United States

Circulating tumor cells (CTC) are rare malignant cells found in the peripheral blood of patients with a wide range of solid tumors. In this study we investigated the correlation of CTC counts with the prostate tumor volume, tissue perfusion and diffusion properties, estimated from multiparametric (MP)-MRI. These imaging biomarkers were related to CTC counts in patients enrolled in a contemporary randomized clinical trial for definitive radiotherapy of prostate cancer. This is, to our knowledge, the first study comparing CTC counts with in vivo measurements of tumor volume, perfusion and diffusion.

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