Abstract #1050
Assessment of Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion
Hsin-Yu Chen 1,2 , Peder E.Z. Larson 1,2 , Robert A. Bok 2 , Cornelius von Morze 2 , Romelyn Delos Santos 2 , Renuka Sriram 2 , Justin Delos Santos 2 , John Kurhanewicz 1,2 , and Daniel B. Vigneron 1,2
1
Graduate Program in Bioengineering, UCSF and
UC Berkeley, San Francisco, California, United States,
2
Department
of Radiology and Biomedical Imaging, University of
California, San Francisco, San Francisco, California,
United States
A major challenge in the clinical management of prostate
cancer is the differentiation of aggressive cancer from
indolent disease. We developed a novel protocol using
dynamic 3D compressed sensing EPSI to quantitatively
assess aggressive prostate cancer on transgenic mouse
model of prostate cancer (TRAMP) using dual agent
hyperpolarized [C13]-pyruvate & [C13]-urea for
simultaneous metabolic and perfusion MR. The dynamic HP
[C13] results demonstrated significantly (P<.001) higher
rates of lactate production and lower perfusion (P<.003)
in high grade tumors versus low grade.
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