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Abstract #1050

Assessment of Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion

Hsin-Yu Chen 1,2 , Peder E.Z. Larson 1,2 , Robert A. Bok 2 , Cornelius von Morze 2 , Romelyn Delos Santos 2 , Renuka Sriram 2 , Justin Delos Santos 2 , John Kurhanewicz 1,2 , and Daniel B. Vigneron 1,2

1 Graduate Program in Bioengineering, UCSF and UC Berkeley, San Francisco, California, United States, 2 Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, United States

A major challenge in the clinical management of prostate cancer is the differentiation of aggressive cancer from indolent disease. We developed a novel protocol using dynamic 3D compressed sensing EPSI to quantitatively assess aggressive prostate cancer on transgenic mouse model of prostate cancer (TRAMP) using dual agent hyperpolarized [C13]-pyruvate & [C13]-urea for simultaneous metabolic and perfusion MR. The dynamic HP [C13] results demonstrated significantly (P<.001) higher rates of lactate production and lower perfusion (P<.003) in high grade tumors versus low grade.

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