Abstract #1058
Property Differences in White Matter Structures due to Distinct Wave Propagation Directions in MR Elastography
Aaron T Anderson 1 , Curtis L Johnson 2 , Joseph L Holtrop 2,3 , Elijah EW Van Houten 4,5 , Mathew DJ McGarry 5 , Keith D Paulsen 5,6 , Bradley P Sutton 2,3 , and John G Georgiadis 1,2
1
Mechanical Science & Engineering, University
of Illinois at Urbana-Champaign, Urbana, IL, United
States,
2
Beckman
Institute for Advanced Science, University of Illinois
at Urbana-Champaign, Urbana, IL, United States,
3
Bioengineering,
University of Illinois at Urbana-Champaign, Urbana, IL,
United States,
4
Département
de Génie Mécanique, Université de Sherbrooke,
Sherbrooke, QC, Canada,
5
Thayer
School of Engineering, Dartmouth College, Hanover, NH,
United States,
6
Dartmouth-Hitchcock
Medical Center, Lebanon, NH, United States
Magnetic resonance elastography (MRE) is an emerging
technique for characterizing the mechanical property
changes in the brain during aging or when it is affected
by a neurodegenerative disease. The success of MRE as a
diagnostic technique relies on improving the fidelity of
material property reconstructions. The isotropic-based
nonlinear inversion of the material property maps
predicts significant differences when distinctly
different wave propagation fields are used. Analyzing
the wave direction relative to neuron bundle orientation
informs our understanding of the effects on the
isotropic model and points to the need for improved
material models characterizing the microstructure.
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