Abstract #1060
Magnetic Resonance Elastography in the presence of iron overload
Najat Salameh 1,2 , Mathieu Sarracanie 1,2 , Christian Farrar 1 , David E J Waddington 1,3 , Bo Zhu 1,4 , Arnaud Comment 5 , and Matthew S Rosen 1,2
1
MGH/A.A. Martinos Center for Biomedical
Imaging, Charlestown, MA, United States,
2
Department
of Physics, Harvard University, Cambridge, MA, United
States,
3
ARC
Centre of Excellence for Engineered Quantum Systems,
University of Sydney, Sydney, NSW, Australia,
4
Harvard-MIT,
Division of Health Sciences and Technology, Cambridge,
MA, United States,
5
Institute
of Physics of Biological Systems, cole Polytechnique
Fdrale de Lausanne, Lausanne, Switzerland
MR elastography cannot be performed in subjects with
iron overload due to both a dramatic drop of signal on
the MR images, and strong magnetic susceptibility
artifacts. We propose in this work an alternative to
biopsy for patients with chronic liver diseases where
MRE has already shown its robustness in staging liver
fibrosis and even in the diagnosis of steatohepatitis
before fibrosis appears. For that purpose, we
implemented a high performance MRE sequence on a 6.5 mT
scanner. We successfully performed MRE in samples
prepared with different iron content and compared our
performance to standard clinical 1.5 T scanners.
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