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Abstract #1060

Magnetic Resonance Elastography in the presence of iron overload

Najat Salameh 1,2 , Mathieu Sarracanie 1,2 , Christian Farrar 1 , David E J Waddington 1,3 , Bo Zhu 1,4 , Arnaud Comment 5 , and Matthew S Rosen 1,2

1 MGH/A.A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 2 Department of Physics, Harvard University, Cambridge, MA, United States, 3 ARC Centre of Excellence for Engineered Quantum Systems, University of Sydney, Sydney, NSW, Australia, 4 Harvard-MIT, Division of Health Sciences and Technology, Cambridge, MA, United States, 5 Institute of Physics of Biological Systems, cole Polytechnique Fdrale de Lausanne, Lausanne, Switzerland

MR elastography cannot be performed in subjects with iron overload due to both a dramatic drop of signal on the MR images, and strong magnetic susceptibility artifacts. We propose in this work an alternative to biopsy for patients with chronic liver diseases where MRE has already shown its robustness in staging liver fibrosis and even in the diagnosis of steatohepatitis before fibrosis appears. For that purpose, we implemented a high performance MRE sequence on a 6.5 mT scanner. We successfully performed MRE in samples prepared with different iron content and compared our performance to standard clinical 1.5 T scanners.

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