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Abstract #1062

Magnetization transfer ratio detects myelin loss in thalamocortical pathways more consistently than DTI after a traumatic brain injury in rat

Lauri Juhani Lehto 1 , Alejandra Sierra 1 , Asla Pitknen 1,2 , and Olli Grhn 1

1 Neurobiology, University of Eastern Finland, Kuopio, Eastern Finland, Finland, 2 Neurology, Kuopio University Hospital, Kuopio, Eastern Finland, Finland

Magnetization transfer (MT) weighted imaging and diffusion tensor imaging (DTI) were performed in rats with experimental traumatic brain injury (TBI) at six months post-TBI. Results were validated by analyzing histological sections. MT ratio (MTR) followed consistently the severity of myelin loss whereas fractional anisotropy gave seemingly mixed results. In line with histology, MTR revealed cortical and white matter damage ipsilateral to injury, particularly in the myelinated thalamocortical pathway. MTR appears be a more sensitive tool than DTI for assessing changes in the myelin integrity after TBI.

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