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Abstract #1063

Voxelwise DTI group analysis in professional fighter population

Wanyong Shin 1 , Blessy Mathew 1 , Banks Sarah 2 , Mark J Lowe 1 , Michael Phillips 1 , Modic T Michael 3 , and Charles Bernick 2

1 Imaging Institute, Cleveland Clinic Foundatoin, Cleveland, Ohio, United States, 2 Lou Ruvo Center for Brain Health, Cleveland Clinic Foundation, Las Vegas, Nervada, United States, 3 Neurological Institute, Cleveland Clinic Founcatoin, Cleveland, Ohio, United States

The Professional Fighters Brain Health Study (PFBHS) is a longitudinal cohort study that is following active professional fighters annually over 4 years. From the initial data including 74 boxers and 84 mixed martial art (MMA) fighters, ROI based DTI results have been published that show that the number of times a fighter has been knocked out (NKO) predicts DTI changes mainly in posterior corpus callosum. [1]. In this study, we included all the baseline visits of the male fighters in PFBHS (N=305) and performed a voxelwise DTI group analysis using non-linear registration method to investigate if fight exposure history predicts DTI measures of white matter integrity in whole brain. We found that NKO predicts DTI changes mainly in corpus callosum and splenium of corpus callosum after controlling age and education effects.

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