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Abstract #1064

Widespread hemodynamic disturbance following experimental TBI

Justin Alexander Long 1 , Lora Talley Watts 1,2 , Wei Li 1 , Qiang Shen 1 , Shiliang Huang 1 , and Timothy Q. Duong 1,3

1 Research Imaging Institute, UTHSCSA, San Antonio, Texas, United States, 2 Department of Cellular and Structural Biology, UTHSCSA, San Antonio, Texas, United States, 3 Department of Ophthamology and Radiology, UTHSCSA, San Antonio, Texas, United States

We previously reported T2 and diffusion following mild TBI in a rat model. However, it is unclear how the widespread hemodynamic disruption affects perilesional tissue outcome. This study evaluated the effects of CBF and cerebrovascular reactivity deficits on diffusion, T2 and fractional anisotropy by analyzing tissue in the impact area and its surrounding. Multimodal MRI measurements were made longitudinally from 1 hour and up to 14 days post TBI. Comparisons were also made with behavioral assessments.

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