Abstract #1064
Widespread hemodynamic disturbance following experimental TBI
Justin Alexander Long 1 , Lora Talley Watts 1,2 , Wei Li 1 , Qiang Shen 1 , Shiliang Huang 1 , and Timothy Q. Duong 1,3
1
Research Imaging Institute, UTHSCSA, San
Antonio, Texas, United States,
2
Department
of Cellular and Structural Biology, UTHSCSA, San
Antonio, Texas, United States,
3
Department
of Ophthamology and Radiology, UTHSCSA, San Antonio,
Texas, United States
We previously reported T2 and diffusion following mild
TBI in a rat model. However, it is unclear how the
widespread hemodynamic disruption affects perilesional
tissue outcome. This study evaluated the effects of CBF
and cerebrovascular reactivity deficits on diffusion, T2
and fractional anisotropy by analyzing tissue in the
impact area and its surrounding. Multimodal MRI
measurements were made longitudinally from 1 hour and up
to 14 days post TBI. Comparisons were also made with
behavioral assessments.
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