Neuroprotective effects of Delayed Methylene Blue in Mild Traumatic Brain Injury

Methylene blue (MB) has energy-enhancing and antioxidant properties. We previously showed that MB given one-hour post TBI had neuroprotective effects in rats. This study investigated the neuroprotective effect of delayed MB treatment (24 hrs) as measured by lesion volume and functional outcome. Comparisons were made with vehicle and acute (1 hr) treatment. We found that delayed MB treatment minimized lesion volume and functional deficits compared to vehicle-treated animals. MB has an excellent safety profile and is clinically approved for other indications. MB clinical trials on TBI can thus be readily explored.

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