Abstract #1066
Using Functional and Molecular MRI Techniques to Detect Neuroprotection by Pinocembrin in Rats Subjected to Traumatic Brain Injury
Wenzhu Wang 1 , Dong-Hoon Lee 2 , Hong Zhang 2 , Jinyuan Zhou 2 , and Jian Wang 1
1
Department of Anesthesiology and Critical
Care Medicine, Johns Hopkins University, Baltimore,
Maryland, United States,
2
Department
of Radiology, Johns Hopkins University, Baltimore,
Maryland, United States
We applied several MRI modalities, T2-weighted,
T2*-weighted, T2, isotropic apparent diffusion
coefficient (ADC), arterial spin labeling-based cerebral
blood flow (CBF), and amide proton transfer
(APT)-weighted (APTw) sequences to several rats with
traumatic brain injury (TBI) that were treated with
pinocembrin (5 or 10 mg/kg). Our results show that
flavonoid pinocembrin is neuroprotective in the TBI
model in rats. The multiple MRI (particularly APTw)
could have potential clinical applications as a unique,
sensitive biomarker for identification and assessment of
neuroinflammation in the TBI model.
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