Meeting Banner
Abstract #1066

Using Functional and Molecular MRI Techniques to Detect Neuroprotection by Pinocembrin in Rats Subjected to Traumatic Brain Injury

Wenzhu Wang 1 , Dong-Hoon Lee 2 , Hong Zhang 2 , Jinyuan Zhou 2 , and Jian Wang 1

1 Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, United States, 2 Department of Radiology, Johns Hopkins University, Baltimore, Maryland, United States

We applied several MRI modalities, T2-weighted, T2*-weighted, T2, isotropic apparent diffusion coefficient (ADC), arterial spin labeling-based cerebral blood flow (CBF), and amide proton transfer (APT)-weighted (APTw) sequences to several rats with traumatic brain injury (TBI) that were treated with pinocembrin (5 or 10 mg/kg). Our results show that flavonoid pinocembrin is neuroprotective in the TBI model in rats. The multiple MRI (particularly APTw) could have potential clinical applications as a unique, sensitive biomarker for identification and assessment of neuroinflammation in the TBI model.

This abstract and the presentation materials are available to members only; a login is required.

Join Here