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Abstract #1067

Mapping of glucose concentration in mild traumatic brain injury via glucoCEST

Tsang-Wei Tu 1 , Rashida Williams 2 , Neekita Jikaria 3 , L. Christine Turtzo 3 , and Joseph Frank 2

1 Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD - Maryland, United States, 2 Radiology and Imaging Sciences, National Institutes of Health, Maryland, United States, 3 National Institutes of Health, Maryland, United States

Tramatic brain injury(TBI) results in an instant increase in cerebral metabolic rates to fulfill the cellular energy requirements to maintain transmembrane potential. Glucose is the main energy souce of brain but after traumatic insult levels decrease dramatically. The energy substrate supply and consumption is crucial for the survival of traumatized brain tissue after TBI. In this study, we conducted the asymmetry analysis of non-chemical exchange saturation transfer (CEST) MRI experiments on 9.4T scaner to study the glucose distribution after mild TBI. Our results indicate that the CEST asymmetry analysis could be a sensitive marker to measure glucose distribution non-invasively after TBI.

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