Abstract #1067
Mapping of glucose concentration in mild traumatic brain injury via glucoCEST
Tsang-Wei Tu 1 , Rashida Williams 2 , Neekita Jikaria 3 , L. Christine Turtzo 3 , and Joseph Frank 2
1
Radiology and Imaging Sciences, National
Institutes of Health, Bethesda, MD - Maryland, United
States,
2
Radiology
and Imaging Sciences, National Institutes of Health,
Maryland, United States,
3
National
Institutes of Health, Maryland, United States
Tramatic brain injury(TBI) results in an instant
increase in cerebral metabolic rates to fulfill the
cellular energy requirements to maintain transmembrane
potential. Glucose is the main energy souce of brain but
after traumatic insult levels decrease dramatically. The
energy substrate supply and consumption is crucial for
the survival of traumatized brain tissue after TBI. In
this study, we conducted the asymmetry analysis of
non-chemical exchange saturation transfer (CEST) MRI
experiments on 9.4T scaner to study the glucose
distribution after mild TBI. Our results indicate that
the CEST asymmetry analysis could be a sensitive marker
to measure glucose distribution non-invasively after
TBI.
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