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Abstract #1069

3D Echo-Planar Spectroscopic Imaging based Metabolic Imaging and Assessment of Whole Brain Temperature in Brain Injuries

Bhanu Prakash KN 1 , Sanjay Kumar Verma 1 , Yevgen Marchenko 1 , Suresh Anand Sadananthan 2 , Yang Ming 3 , Sein Lwin 3 , Charmaine Childs 4 , Yeo Tseng Tsai 3 , Lu Jia 5 , Andrew Maudsley 6 , and Sendhil Velan S 1,2

1 Laboratory of Molecular Imaging, Singapore Bioimaging Consortium, A*STAR, Singapore, 2 Singapore Institute for Clinical Sciences, A*STAR, Singapore, 3 Division of Neurosurgery, National University Health Sciences, Singapore, 4 Centre for Health and Social Care Research, Faculty of Health and Wellbeing, Sheffield Hallam University, United Kingdom, 5 Combat Protection and Performance Lab, Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore, 6 Miller School of Medicine, University of Miami, Miami, Florida, United States

Measurement of whole brain temperature is of relevance in traumatic brain injuries including survival outcome of patients. Whole brain 3D MRSI approach with interleaved water acquisition and larger spatial coverage is highly desirable for assessing changes in cerebral metabolism and investigation of hot spots. In this study, we have implemented 3D EPSI on a clinical Siemens 3T Tim Trio scanner to evaluate the brain temperature changes in control and mild traumatic brain injuries (TBI). Brain temperature across the brain was investigated in Control and mild TBI subjects. Reduction in acquisition time along with high spatial resolution allows translation of this technology to a clinical setting.

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