Abstract #1069
3D Echo-Planar Spectroscopic Imaging based Metabolic Imaging and Assessment of Whole Brain Temperature in Brain Injuries
Bhanu Prakash KN 1 , Sanjay Kumar Verma 1 , Yevgen Marchenko 1 , Suresh Anand Sadananthan 2 , Yang Ming 3 , Sein Lwin 3 , Charmaine Childs 4 , Yeo Tseng Tsai 3 , Lu Jia 5 , Andrew Maudsley 6 , and Sendhil Velan S 1,2
1
Laboratory of Molecular Imaging, Singapore
Bioimaging Consortium, A*STAR, Singapore,
2
Singapore
Institute for Clinical Sciences, A*STAR, Singapore,
3
Division
of Neurosurgery, National University Health Sciences,
Singapore,
4
Centre
for Health and Social Care Research, Faculty of Health
and Wellbeing, Sheffield Hallam University, United
Kingdom,
5
Combat
Protection and Performance Lab, Defence Medical and
Environmental Research Institute, DSO National
Laboratories, Singapore,
6
Miller
School of Medicine, University of Miami, Miami, Florida,
United States
Measurement of whole brain temperature is of relevance
in traumatic brain injuries including survival outcome
of patients. Whole brain 3D MRSI approach with
interleaved water acquisition and larger spatial
coverage is highly desirable for assessing changes in
cerebral metabolism and investigation of hot spots. In
this study, we have implemented 3D EPSI on a clinical
Siemens 3T Tim Trio scanner to evaluate the brain
temperature changes in control and mild traumatic brain
injuries (TBI). Brain temperature across the brain was
investigated in Control and mild TBI subjects. Reduction
in acquisition time along with high spatial resolution
allows translation of this technology to a clinical
setting.
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