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Abstract #1070

Leveraging abnormal structural integrity to enhance detection of disease-specific alterations in functional connectivity.

Roman Fleysher 1 , Susan Sotardi 1 , Michael Stockman 1 , Namhee Kim 1 , David Gutman 1 , Jeremy Smith 1 , Craig A. Branch 1 , and Michael L. Lipton 1

1 Gruss Magnetic Resonance Research Center, Department of Radiology, Albert Einstein College of Medicine, Bronx, New York, United States

Linking evidence of structural damage to functional consequences in brain disorders remains essential for advancing the diagnostic utility of DTI. Many successful investigations into their role employed diffusion measures of structural white matter integrity and BOLD fMRI measures of functional connectivity. This approach is inherently limited by the essentially separate and parallel nature of its structural and functional methodologies. We propose a method enhancing ability to establish structural-to-functional consequences link by eliminating the need for predefined ROIs and by directly coupling functional to structural arms of the analysis. We illustrate this method in a cohort of mTBI patients.

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