Leveraging abnormal structural integrity to enhance detection of disease-specific alterations in functional connectivity.
Roman Fleysher 1 , Susan Sotardi 1 , Michael Stockman 1 , Namhee Kim 1 , David Gutman 1 , Jeremy Smith 1 , Craig A. Branch 1 , and Michael L. Lipton 1
Gruss Magnetic Resonance Research Center,
Department of Radiology, Albert Einstein College of
Medicine, Bronx, New York, United States
Linking evidence of structural damage to functional
consequences in brain disorders remains essential for
advancing the diagnostic utility of DTI. Many successful
investigations into their role employed diffusion
measures of structural white matter integrity and BOLD
fMRI measures of functional connectivity. This approach
is inherently limited by the essentially separate and
parallel nature of its structural and functional
methodologies. We propose a method enhancing ability to
establish structural-to-functional consequences link by
eliminating the need for predefined ROIs and by directly
coupling functional to structural arms of the analysis.
We illustrate this method in a cohort of mTBI patients.
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