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Abstract #1071

Mapping of Cerebral Oxidative Metabolism in Concussion Patients

Xiang He 1 , Serter Gumus 2 , Hoi-Chung Leung 3 , Parsey Ramin 4 , Mark Schweitzer 1 , Marion Hughes 2 , Lea Alhilali 2 , and Saeed Fakhran 2

1 Department of Radiology, Stony Brook University, Stony Brook, New York, United States, 2 Department of Radiology, University of Pittsburgh Medical Center, pennsylvania, United States, 3 Department of Psychology, Stony Brook University, New York, United States, 4 Department of Psychiatry, Stony Brook University, New York, United States

Abnormal cerebral oxidative metabolism (CMRO2) plays a significant role to the pathophysiology of concussion. This study constitutes one of the first MRI-based approaches to investigate the regional cerebral oxidative metabolism and oxidative stress in post-concussion patients. By combining MR-qBOLD and pCASL techniques, depressed gray matter CMRO2 and CBF has been observed in concussion patient, consistent with the findings using FDG-PET on glucose metabolism. Hence, the proposed technique provides a potential tool to non-invasively monitor the brain metabolic response in mTBI without radiation, which is especially important to study sports-related concussion in adolescent and young patients.

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