Abstract #1071
Mapping of Cerebral Oxidative Metabolism in Concussion Patients
Xiang He 1 , Serter Gumus 2 , Hoi-Chung Leung 3 , Parsey Ramin 4 , Mark Schweitzer 1 , Marion Hughes 2 , Lea Alhilali 2 , and Saeed Fakhran 2
1
Department of Radiology, Stony Brook
University, Stony Brook, New York, United States,
2
Department
of Radiology, University of Pittsburgh Medical Center,
pennsylvania, United States,
3
Department
of Psychology, Stony Brook University, New York, United
States,
4
Department
of Psychiatry, Stony Brook University, New York, United
States
Abnormal cerebral oxidative metabolism (CMRO2) plays a
significant role to the pathophysiology of concussion.
This study constitutes one of the first MRI-based
approaches to investigate the regional cerebral
oxidative metabolism and oxidative stress in
post-concussion patients. By combining MR-qBOLD and
pCASL techniques, depressed gray matter CMRO2 and CBF
has been observed in concussion patient, consistent with
the findings using FDG-PET on glucose metabolism. Hence,
the proposed technique provides a potential tool to
non-invasively monitor the brain metabolic response in
mTBI without radiation, which is especially important to
study sports-related concussion in adolescent and young
patients.
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