Abstract #1076
Hyperpolarized 13C diffusion MRS of copolarized pyruvate and fumarate detects evidence for increased lactate export in 8932 pancreas carcinoma cells compared to MCF-7 cells
Benedikt Feuerecker 1 , Markus Durst 2 , Dieter Saur 3 , Marion I Menzel 4 , Markus Schwaiger 1 , and Franz Schilling 1
1
Nuclear Medicine, Technische Universitt
Mnchen, Munich, Bavaria, Germany,
2
GE
Global Research, Munich, Germany,
3
Internal
Medicine, Technische Universitt Mnchen, Munich,
Bavaria, Germany,
4
GE
Global Research, Garching, Bavaria, Germany
Upregulation of glycolysis in tumors results in
increased lactate concentrations in both intra- and
extratumoral areas, the latter leading to an
acidification of the tumor microenvironment.
Hyperpolarized 13C-labelled metabolic tracers can be
used to probe fast metabolic pathways in real-time,
however little has been known from these measurements
about their presence in intra- or extracellular
compartments. In this study we demonstrated that a
combination of copolarized C-13 labeled pyruvate and
fumarate with ADC measurements holds promise for
localizing necrosis and assessing lactate export rate, a
parameter that has been shown to correlate with tumor
aggressiveness.
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