Abstract #1077
High spatial resolution DWI for evaluation of breast tumor early treatment response: Association of ADC changes with pCR
Lisa J Wilmes 1 , Wei-Ching Lo 1 , Wen Li 1 , David C Newitt 1 , Suchandrima Banerjee 2 , Evelyn Proctor 1 , Emine U Saritas 3 , Ajit Shankaranarayanan 2 , and Nola M Hylton 1
1
University of California San Francisco, San
Francisco, CA, United States,
2
GE
Healthcare, Menlo Park, CA, United States,
3
Bilkent
University, Ankara, Turkey
This work measured tumor ADC using a high resolution
reduced field of view diffusion weighted imaging (HR-DWI)
technique and investigated the resultant tumor apparent
diffusion coefficient (ADC) metrics as predictors of
pathologic complete response (pCR) in patients with
locally advanced breast cancer undergoing neoadjuvant
chemotherapy. For early percent change in tumor ADC a
trend of increasing AUC with decreasing percentile ADC
was observed. Additionally, at the early treatment time
point the AUCs for the lower percentile tumor ADC were
higher than for the early tumor volume change.
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