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Abstract #1077

High spatial resolution DWI for evaluation of breast tumor early treatment response: Association of ADC changes with pCR

Lisa J Wilmes 1 , Wei-Ching Lo 1 , Wen Li 1 , David C Newitt 1 , Suchandrima Banerjee 2 , Evelyn Proctor 1 , Emine U Saritas 3 , Ajit Shankaranarayanan 2 , and Nola M Hylton 1

1 University of California San Francisco, San Francisco, CA, United States, 2 GE Healthcare, Menlo Park, CA, United States, 3 Bilkent University, Ankara, Turkey

This work measured tumor ADC using a high resolution reduced field of view diffusion weighted imaging (HR-DWI) technique and investigated the resultant tumor apparent diffusion coefficient (ADC) metrics as predictors of pathologic complete response (pCR) in patients with locally advanced breast cancer undergoing neoadjuvant chemotherapy. For early percent change in tumor ADC a trend of increasing AUC with decreasing percentile ADC was observed. Additionally, at the early treatment time point the AUCs for the lower percentile tumor ADC were higher than for the early tumor volume change.

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