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Abstract #1090

Highly Accelerated DCE-MRI Pharmacokinetic map Estimation through frequency domain based Tofts model (HAET)

Nithin N Vajuvalli 1 , C K Dharmendra Kumar 1 , Manoj G Bhosale 1,2 , and Sairam Geethanath 1

1 Medical Imaging Research Centre, Dayananda Sagar College of Engineering, Bangalore, Karnataka, India, 2 Government College of Engineering (COEP), Pune, Maharastra, India

DCE-MRI is used to assess tumor perfusion, microvascular vessel wall permeability and extravascularextracellular volume fraction. Tofts Model (TM) in Time Domain (TD) is computationally intensive for 3D data to obtain Pharmacokinetic (PK) map using curve fitting. The current work involves acceleration of curve fitting process for the computation of PK map using Frequency Domain (FD) based TM. Current work was demonstrated on seven breast DCE datasets. Result show reduced computational time for estimating PK map and reduced NRMSE values in FD as compared to TD tofts model with respect to randomly generated ground truth and in vivo data.

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