Abstract #1089
Optimisation of b-value Distribution for Intravoxel Incoherent Motion (IVIM) Imaging of Breast Cancer with Clinical Results
Nina L. Purvis 1 , Peter Gibbs 2 , Martin D. Pickles 2 , and Lindsay W. Turnbull 2
1
Centre for MR Investigations, Hull York
Medical School, Hull, East Yorkshire, United Kingdom,
2
Centre
for MR Investigations, University of Hull at HYMS, Hull,
East Yorkshire, United Kingdom
An investigation to find an optimised clinical b-value
protocol for IVIM imaging in breast lesions and its
application. B-value schemes were generated using
exponential and power-law spacing then the Cramer-Rao
Lower Bound of IVIM parameters was calculated. A b-value
scheme was chosen based on a figure of merit to balance
the relative errors of the parameters. Data was fitted
using mono and bi-exponential models. The RMSEs
indicated that the biexponential fit was better. The
results agree well with previously reported values. The
b-value scheme samples low b-values well, and allows an
acceptable amount of NEX for a short scan duration.
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