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Abstract #1088

A Comparison of Breast Tissue T1 Mapping Using Conventional Multi-flip Angle and 2-point Dixon Techniques

Reem Bedair 1 , Mary McLean 2 , Andrew Patterson 3 , Roie Manavaki 1 , John Griffiths 2 , Fiona Gilbert 1 , and Martin Graves 3

1 University of Cambridge, Department of Radiology, Cambridge, Cambridgeshire, United Kingdom, 2 Cancer Research UK Cambridge Research Institute, Cambridge, Cambridgeshire, United Kingdom, 3 Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, Cambridgeshire, United Kingdom

T10 mapping acquisitions of quantitative DCE-MRI is generally performed without fat suppression. Recent studies have used 2-point Dixon (2PD) reconstruction as a time-effective method for obtaining robust water-only images. This work compares the pre-contrast T10 relaxation times obtained using a conventional non-fat suppressed multiple flip angle technique with a fat-suppressed 2PD method in a cohort of patients with locally advanced breast cancer at 3.0T. Our results show an increase in the T1 measurement of fibroglandular tissue on fat suppression. However, the mean T10 values in tumours decrease. Our study demonstrates the feasibility of rapid fat-suppression techniques for quantitative DCE-MRI analysis.

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