Abstract #1088
A Comparison of Breast Tissue T1 Mapping Using Conventional Multi-flip Angle and 2-point Dixon Techniques
Reem Bedair 1 , Mary McLean 2 , Andrew Patterson 3 , Roie Manavaki 1 , John Griffiths 2 , Fiona Gilbert 1 , and Martin Graves 3
1
University of Cambridge, Department of
Radiology, Cambridge, Cambridgeshire, United Kingdom,
2
Cancer
Research UK Cambridge Research Institute, Cambridge,
Cambridgeshire, United Kingdom,
3
Department
of Radiology, Cambridge University Hospitals NHS
Foundation Trust, Cambridge, Cambridgeshire, United
Kingdom
T10 mapping acquisitions of quantitative DCE-MRI is
generally performed without fat suppression. Recent
studies have used 2-point Dixon (2PD) reconstruction as
a time-effective method for obtaining robust water-only
images. This work compares the pre-contrast T10
relaxation times obtained using a conventional non-fat
suppressed multiple flip angle technique with a
fat-suppressed 2PD method in a cohort of patients with
locally advanced breast cancer at 3.0T. Our results show
an increase in the T1 measurement of fibroglandular
tissue on fat suppression. However, the mean T10 values
in tumours decrease. Our study demonstrates the
feasibility of rapid fat-suppression techniques for
quantitative DCE-MRI analysis.
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