Abstract #1097
OKN-007 decreases tumor necrosis and tumor cell proliferation and increases apoptosis in a pre-clinical F98 rat glioma model
Rheal A. Towner 1 , Patricia Coutinho De Souza 1 , Krithika Balasubramanian 2 , Charity Njoku 1 , Nataliya Smith 1 , David L. Gillespie 3 , Andrea Schwager 4 , Osama Abdullah 5 , Kar-Ming Fung 6 , Debra Saunders 1 , and Randy L. Jensen 3
1
Advanced Magnetic Resonance Center, Oklahoma
Medical Research Foundation, Oklahoma City, OK, United
States,
2
Radiology
& Biomedical Imaging, University of California San
Francisco, CA, United States,
3
Huntsman
Cancer Insitute, University of Utah Health Sciences
Center, UT, United States,
4
Neurobiology
& Anatomy, University of Utah Health Sciences Center,
UT, United States,
5
Small
Animal Core Facility, University of Utah, UT, United
States,
6
Pathology,
University of Oklahoma Health Sciences Center, OK,
United States
Gliomas are the most lethal adult primary brain tumors
with a poor outcome. Here, we report the effects of
OKN-007 on the necrotic tumor core and non-necrotic
tumor parenchyma in the F98 rat glioma model assessed by
1H-MRSI, DWI, and histological analysis. Our results
that OKN-007 was able to reduce necrosis and tumor cell
proliferation. There was also an increase in apoptosis
following OKN-007 treatment which seemed to correlate
with spectroscopic lipid peak assessments. Our results
also indicated that both ADC and spectroscopic choline
measures are related to glioma cell density in the F98
rat glioma model.
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