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Abstract #1097

OKN-007 decreases tumor necrosis and tumor cell proliferation and increases apoptosis in a pre-clinical F98 rat glioma model

Rheal A. Towner 1 , Patricia Coutinho De Souza 1 , Krithika Balasubramanian 2 , Charity Njoku 1 , Nataliya Smith 1 , David L. Gillespie 3 , Andrea Schwager 4 , Osama Abdullah 5 , Kar-Ming Fung 6 , Debra Saunders 1 , and Randy L. Jensen 3

1 Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK, United States, 2 Radiology & Biomedical Imaging, University of California San Francisco, CA, United States, 3 Huntsman Cancer Insitute, University of Utah Health Sciences Center, UT, United States, 4 Neurobiology & Anatomy, University of Utah Health Sciences Center, UT, United States, 5 Small Animal Core Facility, University of Utah, UT, United States, 6 Pathology, University of Oklahoma Health Sciences Center, OK, United States

Gliomas are the most lethal adult primary brain tumors with a poor outcome. Here, we report the effects of OKN-007 on the necrotic tumor core and non-necrotic tumor parenchyma in the F98 rat glioma model assessed by 1H-MRSI, DWI, and histological analysis. Our results that OKN-007 was able to reduce necrosis and tumor cell proliferation. There was also an increase in apoptosis following OKN-007 treatment which seemed to correlate with spectroscopic lipid peak assessments. Our results also indicated that both ADC and spectroscopic choline measures are related to glioma cell density in the F98 rat glioma model.

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