Abstract #1098
Oxidative ketone body metabolism in rat brain tumors and the effect of the ketogenic diet: evidence from in vivo 1 H-[ 13 C] MRS
Henk M. De Feyter 1 , Kevin L. Behar 2 , Kevan L. Ip 1 , Fahmeed Hyder 1 , Lester L. Drewes 3 , Robin A. de Graaf 1 , and Douglas L. Rothman 1
1
Department of Diagnostic Radiology, Yale
University, New Haven, Connecticut, United States,
2
Department
of Psychiatry, Yale University, CT, United States,
3
Department
of Biomedical Sciences, University of Minnesota, MN,
United States
The ketogenic diet (KD; fat, protein, no carbohydrates)
creates a plasma nutrient profile similar to starvation:
increased levels of ketone bodies and reduced plasma
glucose levels, and has been proposed as metabolic
therapy for brain tumors. Brain tumor cells supposedly
cannot oxidize ketone bodies for energy metabolism in
contrast to normal brain cells, and therefore the KD
would result in starving of glucose-dependent brain
tumors. We investigated the capability of glioma cells
to oxidize beta-hydroxybutyrate, the most abundant
ketone body, using
13
C
magnetic resonance spectroscopy. 9L and RG2 glioma cells
were studied both
in
vitro
and
in
vivo
while
administering [2,4-
13
C
2
]-
beta-hydroxybutyrate.
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