Meeting Banner
Abstract #1098

Oxidative ketone body metabolism in rat brain tumors and the effect of the ketogenic diet: evidence from in vivo 1 H-[ 13 C] MRS

Henk M. De Feyter 1 , Kevin L. Behar 2 , Kevan L. Ip 1 , Fahmeed Hyder 1 , Lester L. Drewes 3 , Robin A. de Graaf 1 , and Douglas L. Rothman 1

1 Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, United States, 2 Department of Psychiatry, Yale University, CT, United States, 3 Department of Biomedical Sciences, University of Minnesota, MN, United States

The ketogenic diet (KD; fat, protein, no carbohydrates) creates a plasma nutrient profile similar to starvation: increased levels of ketone bodies and reduced plasma glucose levels, and has been proposed as metabolic therapy for brain tumors. Brain tumor cells supposedly cannot oxidize ketone bodies for energy metabolism in contrast to normal brain cells, and therefore the KD would result in starving of glucose-dependent brain tumors. We investigated the capability of glioma cells to oxidize beta-hydroxybutyrate, the most abundant ketone body, using 13 C magnetic resonance spectroscopy. 9L and RG2 glioma cells were studied both in vitro and in vivo while administering [2,4- 13 C 2 ]- beta-hydroxybutyrate.

This abstract and the presentation materials are available to members only; a login is required.

Join Here