Abstract #1101
Mechanical characterization of a mouse GL261 glioma model using MR elastography
Jing Guo 1 , Simon Bayerl 2 , Jrgen Braun 3 , Peter Vajkoczy 2 , and Ingolf Sack 4
1
Radiology, Charit - Universittsmedizin
Berlin, Berlin, Berlin, Germany,
2
Department
of Neurosurgery, Charit - Universittsmedizin Berlin,
Berlin, Germany,
3
Department
of Medical Informatics, Charit - Universittsmedizin
Berlin, Berlin, Germany,
4
Radiology,
Charit - Universittsmedizin Berlin, Berlin, Germany
MR elastography (MRE) was performed to study the
viscoelasticity of glioblastoma (GB) in the GL261 mouse
model. We found that the magnitude of the complex shear
modulus |G*| of the tumor was significantly reduced
while the phase angle showed a large heterogeneity of
values compared to healthy brain tissue. Our results
corroborate clinical studies of MRE in GB and raise the
prospect of assessing tumor malignancy by tissue
mechanical constants.
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