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Abstract #1100

Intravoxel Incoherent Motion Diffusion Weighted Imaging(IVIM-DWI) on a mouse xenografts model of human nasopharyngeal carcinoma CNE-2 cell line: A preliminary study on 3.0T MRI

Youping Xiao 1 , Yunbin Chen 1 , Jianji Pan 2 , Ying Chen 1 , Yiqi Yao 1 , Xiang Zheng 1 , Xiangyi Liu 1 , Dechun Zheng 1 , and Weibo Chen 3

1 Radiology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, China, 2 Radiation Oncology, Fujian Provincial Cancer Hospital, Fuzhou, Fujian, China, 3 Philips Healthcare, Shanghai, China

The results of this present study shows that intravoxel incoherent montion diffusion weighted imaging(IVIM-DWI) derived parameters present a good producibility and feasibility on xenografts of human nasopharyngeal carcinoma(NPC) cell line CNE-2 which have a significant higher D(pure diffusion coefficient) and a lower f(fraction of perfusion) parameter. It is indicated that IVIM-DWI would be valuable in helping evaluate the micro-environment characteristic of diffusion and perfusion in NPC's xenograft, especially during the process of chemoradiotherapy.

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