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Abstract #1105

Correlation of Quantitative MRI-derived Tumor Characteristics with Histology in Breast Cancer Murine Models

Anna G Sorace 1,2 , Stephanie L Barnes 1,2 , Jennifer G Whisenant 1,2 , Mary E Loveless 1 , and Thomas E Yankeelov 1,2

1 Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, United States, 2 Vanderbilt University Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, United States

This study evaluated the relationship between the apparent diffusion coefficient (ADC), the extravascular extracellular volume fraction ( v e ), and quantitative histology measurements using two preclinical breast cancer models, BT474 and MDA-MB-231. Quantitative imaging biomarkers can reveal treatment response, however better validation of the techniques needs to occur prior to translation. While ADC reveals significant correlations with the extracellular space in both preclinical models, this data adds to the growing body of literature which suggests that v e is not a reliable biomarker of extracellular space.

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