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Abstract #1106

Importance of characterizing water content in quantifying metabolites in pancreatic cancer and normal pancreas

Marie-France Penet 1 , Balaji Krishnamachary 1 , Tariq Shah 1 , Yelena Mironchik 1 , Anirban Maitra 2 , and Zaver M Bhujwalla 1

1 JHU ICMIC Program, Division of Cancer Imaging Research, The Russell H Morgan Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2 MD Anderson Cancer Center, The University of Texas, TX, United States

There is a critical need for identifying and developing new noninvasive biomarkers and therapeutic targets in pancreatic cancer. We recently observed aberrant choline metabolism in subcutaneous and orthotopically implanted human pancreatic cancer xenografts using 1H MR spectroscopic imaging. However, high-resolution proton spectra of tumors and pancreatic tissue extracts normalized to the water signal assuming similar water content did not reflect the significantly increased total choline observed in vivo. Our purpose here was to determine the differences in water content between pancreatic tumors and the pancreas to accurately quantify differences in metabolism when using the water signal for normalization.

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