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Abstract #1107

Evaluation of nanoparticle accumulation and treatment efficacy for a combined heavy-ion-beam irradiation and drug-delivery tumor therapy

Daisuke Kokuryo 1 , Eiji Yuba 2 , Kenji Kono 2 , Tsuneo Saga 1 , and Ichio Aoki 1

1 Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba, Japan, 2 Graduate School of Engineering, Osaka Prefecture University, Sakai, Osaka, Japan

A combination treatment using carbon-ion-beam irradiation and multimodal thermo-sensitive polymer-modified liposomes (MTPLs) containing contrast agents and anti-cancer drug was developed. The accumulation and treatment effects of the MTPLs were evaluated in in vivo experiments on subcutaneously xenografted tumor model mice. MTPLs accumulated in the tumor region regardless of the influence of carbon-beam irradiation and the efficacy of the combination treatment increased after heat-triggering of drug release. It was concluded that the proposed strategy provided an effective anti-cancer treatment.

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