Abstract #1108
NMR based pharmacometabolomics for evaluating the drug response of polyherbal formulations
Gaurav Sharma 1 , Somenath Ghatak 1 , Arun Kumar Verma 2 , Thirumurthy Velpandian 3 , and Rama Jayasundar 1
1
NMR, All India Institute of Medical
Sciences, New Delhi, Delhi, India,
2
Biotechnology,
All India Institute of Medical Sciences, New Delhi,
Delhi, India,
3
Pharmacology,
All India Institute of Medical Sciences, New Delhi,
Delhi, India
Although single molecule drugs remain the focus of drug
development, polyherbal formulations are evoking
interest due to their synergistic activity, low toxicity
and multitargeting potential. The objective of this
study is to evaluate the pharmacometabolic response of
chick Chorio-Allantoic Membrane (CAM) to polyherbal
formulations using high resolution NMR and also assess
their antiangiogenic potential using CAM assay. The
significant inhibition of neovascularization by the
formulations comparable to that of the synthetic
chemotherapy drug thalidomide, was reflected in both the
CAM assay and NMR spectral data. In the latter, it
showed as significant reduction in choline, pyruvate,
and lactate peaks.
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