Abstract #1110
Repairing the Brain with Physical Exercise: Insights from Cortical Thickness Analysis of An Exercise Trial in Pediatric Brain Tumor Survivors
Kamila U Szulc 1 , Ade Oyefiade 2 , Lily Riggs 1,2 , Eric Bouffet 3,4 , Suzanne Laughlin 5 , Brian W Timmons 6 , Jason P Lerch 7 , Cynthia B de Medeiros 2 , Jovanka Skocic 1 , and Donald J Mabbott 1,2
1
Neurosciences and Mental Health, Hospital
for Sick Children, Toronto, Ontario, Canada,
2
Department
of Psychology, Hospital for Sick Children, Toronto,
Ontario, Canada,
3
Division
of Haematology/Oncology, Hospital for Sick Children,
Toronto, Ontario, Canada,
4
Department
of Pediatrics, Hospital for Sick Children, Toronto,
Ontario, Canada,
5
Diagnostic
Imaging, Hospital for Sick Children, Toronto, Ontario,
Canada,
6
Department
of Pediatrics, McMaster University, Hamilton, Ontario,
Canada,
7
Mouse
Imaging Centre, Hospital for Sick Children, Toronto,
Ontario, Canada
Cranial radiation is a standard form of treatment for
malignant brain tumors. While radiation increases
survival rates, it also leads to long-term cognitive
impairments and neurodegeneration. Unfortunately, there
is no cure or standard of care for these
treatment-related effects. Recently, there have been a
growing number of studies showing the benefits of
physical activity for the brains of healthy children,
but its potential as a rehabilitative technique remains
unknown. We conducted a 12-week program to examine
whether aerobic exercise can stimulate brain repair
processes in pediatric brain tumor survivors treated
with cranial radiation. Specifically, we examined the
effects of exercise on cortical thickness.
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