Manganese-enhanced MRI of minimally gadolinium-enhancing breast tumors
Hai-Ling Margaret Cheng 1,2 , Tameshwar Ganesh 2 , Reza Bayat Mokhtari 3 , Mosa Alhamami 2 , and Herman Yeger 3
Institute of Biomaterials & Biomedical
Engineering, University of Toronto, Toronto, Ontario,
& Experimental Medicine, Hospital for Sick Children,
Toronto, Ontario, Canada,
& Stem Cell Biology, Hospital for Sick Children,
Toronto, Ontario, Canada
Contrast-enhanced MRI is as essential component of
oncological imaging. However, tumors with low
vascularity, such as some low-grade gliomas, or ones
that become non-enhancing following antiangiogenic
treatment, may not enhance appreciably relative to
surrounding normal tissue. In this study, we investigate
the potential of manganese (Mn)-enhanced MRI for
sensitive detection of tumors that demonstrate little
enhancement on Gd-DTPA. Results in tumor-bearing rats
demonstrated MnCl2 administration achieved greater and
more uniform enhancement throughout the tumor mass (i.e.
was not restricted to tumor periphery). Histology
confirmed very low vascularity, and necrotic areas were
well delineated only on Mn-enhanced MRI.
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