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Abstract #1111

Manganese-enhanced MRI of minimally gadolinium-enhancing breast tumors

Hai-Ling Margaret Cheng 1,2 , Tameshwar Ganesh 2 , Reza Bayat Mokhtari 3 , Mosa Alhamami 2 , and Herman Yeger 3

1 Institute of Biomaterials & Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada, 2 Physiology & Experimental Medicine, Hospital for Sick Children, Toronto, Ontario, Canada, 3 Developmental & Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada

Contrast-enhanced MRI is as essential component of oncological imaging. However, tumors with low vascularity, such as some low-grade gliomas, or ones that become non-enhancing following antiangiogenic treatment, may not enhance appreciably relative to surrounding normal tissue. In this study, we investigate the potential of manganese (Mn)-enhanced MRI for sensitive detection of tumors that demonstrate little enhancement on Gd-DTPA. Results in tumor-bearing rats demonstrated MnCl2 administration achieved greater and more uniform enhancement throughout the tumor mass (i.e. was not restricted to tumor periphery). Histology confirmed very low vascularity, and necrotic areas were well delineated only on Mn-enhanced MRI.

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