Abstract #1117
Quantitative Analysis of Multi-parametric FLT-PET/MRI in Evaluating Early Treatment Response in Renal Cell Carcinoma
Jacob Antunes 1 , Satish Viswanath 1 , Mirabela Rusu 1 , Laia Valls 2 , Norbert Avril 2 , Christopher Hoimes 2 , and Anant Madabhushi 1
1
Center for Computational Imaging and
Personalized Diagnostics, Case Western Reserve
University, Cleveland, OH, United States,
2
University
Hospitals Case Medical Center, Cleveland, OH, United
States
We present a framework for quantitatively evaluating
early treatment response of renal cell carcinoma (RCC).
A single RCC patient was imaged using an integrated
T2W/PET and DWI sequence before and during cytostatic
drug treatment. Sequences within an acquisition protocol
were spatially aligned and co-registered between
acquisition time points. SUV, ADC-map, and T2W textural
feature intensities were extracted on a per-voxel basis.
A weighted difference map combination of multiple
PET/MRI parameters was computed to optimize for expected
changes within annotated RCC and normal tissue regions.
The integrated multi-parametric PET/MRI map demonstrated
high specificity in identifying early treatment response
in metastatic RCC.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
