Early detection of treatment-induced apoptosis in tumors using temporal diffusion spectroscopy MRI

The restoration of apoptosis in cancer cells is a critical strategy in the development of novel anti-cancer therapies. In vivo detection of apoptosis may provide early assessment of therapeutic response, however, none of the current imaging methods have proven robustly successful in clinics. Apoptosis at early stages is associated with significant microstructural variations, including nuclear fragmentation, cytosolic condensation, and cellular shrinkage. Here we show that temporal diffusion spectroscopy, a technique that is capable of characterizing microstructural variations across intracellular to cellular length scales, can provide an early, non-invasive and specific detection of the microstructural variations associated with treatment-induced apoptosis.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.