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Abstract #1118

Early detection of treatment-induced apoptosis in tumors using temporal diffusion spectroscopy MRI

Xiaoyu Jiang 1 , Hua Li 1 , Ping Zhao 1 , H. Charles Manning 1 , Junzhong Xu 1 , and John C. Gore 1

1 Institute of Imaging Science, vanderbilt university, nashville, Tennessee, United States

The restoration of apoptosis in cancer cells is a critical strategy in the development of novel anti-cancer therapies. In vivo detection of apoptosis may provide early assessment of therapeutic response, however, none of the current imaging methods have proven robustly successful in clinics. Apoptosis at early stages is associated with significant microstructural variations, including nuclear fragmentation, cytosolic condensation, and cellular shrinkage. Here we show that temporal diffusion spectroscopy, a technique that is capable of characterizing microstructural variations across intracellular to cellular length scales, can provide an early, non-invasive and specific detection of the microstructural variations associated with treatment-induced apoptosis.

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