Abstract #1126
Differences in phospholipid and lipid metabolism between cancer cells in culture and in solid tumors
Noriko Mori 1 , Flonn Wildes 1 , Tomoyo Takagi 1 , Kristine Glunde 1,2 , and Zaver M. Bhujwalla 1,2
1
The Russell H. Morgan Department of
Radiology and Radiological Science, The Johns Hopkins
University School of Medicine, Baltimore, MD, United
States,
2
The
Sidney Kimmel Comprehensive Cancer Center, The Johns
Hopkins University School of Medicine, MD, United States
Abnormal phospholipid and lipid metabolism are
characteristic features of cancer. Cancer cells in
culture do not completely mirror observations made in
vivo because of the strong influence of the tumor
microenvironment. In our ongoing studies we are
comparing phosphocholine/glycerophosphocholine and lipid
levels in prostate and breast cancer cells and tumors
using 1H MR spectroscopy, to further understand
metabolic processes. We have compared protein levels of
the related enzymes to the metabolisms in these cells
and tumors. Significantly different protein levels
observed between cells in culture and tumors demonstrate
the importance of the tumor microenvironment in
phospholipid and lipid metabolism.
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