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Abstract #1126

Differences in phospholipid and lipid metabolism between cancer cells in culture and in solid tumors

Noriko Mori 1 , Flonn Wildes 1 , Tomoyo Takagi 1 , Kristine Glunde 1,2 , and Zaver M. Bhujwalla 1,2

1 The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2 The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, MD, United States

Abnormal phospholipid and lipid metabolism are characteristic features of cancer. Cancer cells in culture do not completely mirror observations made in vivo because of the strong influence of the tumor microenvironment. In our ongoing studies we are comparing phosphocholine/glycerophosphocholine and lipid levels in prostate and breast cancer cells and tumors using 1H MR spectroscopy, to further understand metabolic processes. We have compared protein levels of the related enzymes to the metabolisms in these cells and tumors. Significantly different protein levels observed between cells in culture and tumors demonstrate the importance of the tumor microenvironment in phospholipid and lipid metabolism.

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