Abstract #1125
Investigation of Prostate Cancer Metabolomics with Prostate Biopsy Cores
Emily Decelle 1 , Taylor Fuss 1 , Shulin Wu 1 , Adam Feldman 2 , Douglas Dahl 2 , Aria Olumi 2 , W Scott McDougal 2 , Chin-Lee Wu 1 , and Leo L Cheng 3
1
Pathology, Massachusetts General Hospital,
Boston, MA, United States,
2
Urology,
Massachusetts General Hospital, Boston, MA, United
States,
3
Pathology
and Radiology, Massachusetts General Hospital, Boston,
MA, United States
Prostate cancer (PCa) is the second leading cause of
cancer death and the most frequently diagnosed
malignancy in men worldwide. Previous observations show
that PCa metabolic information can delocalize from PCa
glands and into histologically-benign tissue creating
field effects resulting in metabolomic lesions that
are larger than histology lesions. In this study, we
evaluate these effects with location defined prostate
biopsy samples from patients suspected of harboring PCa
using high-resolution magic angle spinning MR
spectroscopy at 14.1T with constructions of training and
testing cohorts created through quantitative
histopathology of the biopsy cores.
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