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Abstract #1124

Noninvasive Image-Based Quantification of 18F-fluoromisonidazole (FMISO) Uptake using PET/MRI

Dragana Savic 1 , Youngho Seo 1 , Randall Hawkins 1 , Soonmee Cha 1 , Miguel Pampaloni 1 , Sharmila Majumdar 1 , and Ramon Barajas 1

1 Radiology and Biomedical Imaging, University of California, San Francisco (UCSF), San Francisco, California, United States

We present a non-invasive image-based quantification method for estimating the activity in patients using an investigational simultaneous TOF PET/MRI scanner. Patients were injected with 18F-fluormisonidazole, and the average activity was calculated from the whole blood samples, and compared to the activity from the PET/MRI scanner. The average MRI blood-to-blood ratios were 1.16 and 1.18 respectively for the carotid arteries and the jugular veins. These results suggest that we can do image-derived blood activity concentration calculation reproducibility, and potentially avoid invasive blood sample procedures, by the use of our image derived quantification method using a hybrid simultaneous TOF PET/MRI scanner.

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