Abstract #1124
Noninvasive Image-Based Quantification of 18F-fluoromisonidazole (FMISO) Uptake using PET/MRI
Dragana Savic 1 , Youngho Seo 1 , Randall Hawkins 1 , Soonmee Cha 1 , Miguel Pampaloni 1 , Sharmila Majumdar 1 , and Ramon Barajas 1
1
Radiology and Biomedical Imaging, University
of California, San Francisco (UCSF), San Francisco,
California, United States
We present a non-invasive image-based quantification
method for estimating the activity in patients using an
investigational simultaneous TOF PET/MRI scanner.
Patients were injected with 18F-fluormisonidazole, and
the average activity was calculated from the whole blood
samples, and compared to the activity from the PET/MRI
scanner. The average MRI blood-to-blood ratios were 1.16
and 1.18 respectively for the carotid arteries and the
jugular veins. These results suggest that we can do
image-derived blood activity concentration calculation
reproducibility, and potentially avoid invasive blood
sample procedures, by the use of our image derived
quantification method using a hybrid simultaneous TOF
PET/MRI scanner.
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