Abstract #1123
13C MRS/Bioreactor Technique to Study Melanoma: Quantifying Glutaminolysis and de novo Lipogenesis
Alexander A. Shestov 1 , Anthony Mancuso 2 , Pierre Gilles Henry 3 , Dennis B. Leeper 4 , and Jerry David Glickson 5
1
Radiology, University of Pennsylvania,
Philadelphia, PA, United States,
2
Radiology,
University of Pennsylvania, PA, United States,
3
University
of Minnesota, MN, United States,
4
Radiation
Oncology, Thomas Jefferson University, PA, United
States,
5
Radiology,
Univesity of Pennsylvania, PA, United States
The bioreactor techniques combined with 13C MRS are an
important tool to study cancer cell metabolism. Modeling
of intracellular MRS isotopomer data obtained during
perfusion with 13C labeled substrates allows
quantitative determination of transport and metabolic
parameters in vivo/in situ. In this work, we apply a
novel 13C metabolic flux analysis technique to elucidate
cancer metabolism bionetwork and calculate fluxes
through important cancer metabolic pathways.
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