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Abstract #1134

MRI Functional Parameters in Breast Cancer:T2*, ADC and Contrast Agent Uptake

Evanthia Kousi 1 , Maria A. Schmidt 1 , Marco Borri 1 , Cheryl Richardson 2 , Georgina Hopkinson 2 , Elizabeth A.M. O'Flynn 1 , Robin M. Wilson 2 , Steven Allen 2 , Romney J.E. Pope 2 , and Martin O. Leach 1

1 CR-UK and EPSRC Imaging Centre, Royal Marsden NHS Foundation Trust and Institute of Cancer Reasearch, Sutton, Surrey, United Kingdom, 2 Department of Radiology, Royal Marsden NHS Foundation Trust, Chelsea, London, United Kingdom

T2* relaxation time has been proposed as an imaging biomarker to evaluate hypoxia associated with tumour grade and therapeutic response. In this study, we explore the relationship between T2*, ADC and contrast agent uptake. Substantial variations for all functional parameters detected within tumours. Considerable inter-subject variability observed in the association between T2* and ADC for breast tumours. Less variability observed in the association between T2* and contrast uptake. Considering all patients, T2* and ADC correlated weakly and no correlation observed between T2* and contrast uptake. Our results suggest that T2* is an independent parameter and may provide new clinical information.

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