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Abstract #1135

Magnetization Transfer Ratio variations in malignant breast lesions and parenchyma

Andrew J Patterson 1 , Mary M McLean 2 , Reem Bedair 1 , Andrew N Priest 1 , John R Griffiths 2 , Martin J Graves 1 , and Fiona J Gilbert 1

1 Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, England, United Kingdom, 2 Cancer Research UK Cambridge Insititute, Li Ka Shing Cambridge, Cambridge, England, United Kingdom

Magnetization Transfer Ratio (MTR) quantifies the interactions of water protons with different macromolecular environments. This study reports on changes in MTR in tissue proximal to malignancy and investigates the differences in MTR between tumor type and grade. Thirty patients with biopsy confirmed breast cancer were recruited. MTR maps are computed at 3T following a B1 field correction. This study noted a statistically significant difference between tumor type with the invasive mucinous type having lower MTR. This study finds that parenchyma proximal to malignancy was lower than that of contralateral parenchyma which may be due to desmoplastic reactions.

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