Abstract #1135
Magnetization Transfer Ratio variations in malignant breast lesions and parenchyma
Andrew J Patterson 1 , Mary M McLean 2 , Reem Bedair 1 , Andrew N Priest 1 , John R Griffiths 2 , Martin J Graves 1 , and Fiona J Gilbert 1
1
Department of Radiology, Cambridge
University Hospitals NHS Foundation Trust, Cambridge,
England, United Kingdom,
2
Cancer
Research UK Cambridge Insititute, Li Ka Shing Cambridge,
Cambridge, England, United Kingdom
Magnetization Transfer Ratio (MTR) quantifies the
interactions of water protons with different
macromolecular environments. This study reports on
changes in MTR in tissue proximal to malignancy and
investigates the differences in MTR between tumor type
and grade. Thirty patients with biopsy confirmed breast
cancer were recruited. MTR maps are computed at 3T
following a B1 field correction. This study noted a
statistically significant difference between tumor type
with the invasive mucinous type having lower MTR. This
study finds that parenchyma proximal to malignancy was
lower than that of contralateral parenchyma which may be
due to desmoplastic reactions.
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