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Abstract #1148

Modelling tissue microstructure in bone metastases from prostate cancer using VERDICT MRI

Colleen Bailey 1 , Eleftheria Panagiotaki 1 , Nina Tunariu 2 , Matthew R Orton 3 , Veronica A Morgan 3 , Thorsten Feiweier 4 , David J Hawkes 1 , Martin O Leach 3 , David J Collins 3 , and Daniel C Alexander 1

1 Centre for Medical Image Computing, University College London, London, United Kingdom, 2 Radiology, Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Sutton, United Kingdom, 3 CR-UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, United Kingdom, 4 Healthcare Sector, Siemens AG, Erlangen, Germany

Bone metastases in men with advanced prostate cancer were examined by diffusion MRI with varying diffusion times and gradient strengths. Data were fitted to 3-compartment models of diffusion that included a perfusion compartment, an extracellular compartment and an intracellular spherically-restricted compartment. Data showed variation for points with the same b-value but different diffusion time and were better explained by a model incorporating restriction than either conventional ADC or 2- or 3-compartment models with free diffusion. Model parameters indicated a low perfusion fraction (<10%), intracellular volume fraction 0.22-0.56 and a cell radius between 4.7-9.9 m.

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