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Abstract #1158

The influence of polyamines on metabolite ratios in the prostate at 7 tesla

Mariska P Luttje 1 , Catalina S Arteaga de Castro 2 , Peter R Luijten 1 , Marco van Vulpen 1 , Uulke A van der Heide 2 , and Dennis WJ Klomp 1

1 Imaging Division, University Medical Center Utrecht, Utrecht, Netherlands, 2 Department of Radiotherapy, the Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Amsterdam, Netherlands

In contrast to 1H MRSI at lower field strength, where polyamine signals overlap with choline signals, our results at 7 tesla demonstrate the ability to fit each of the prostate metabolite resonances distinctively. This facilitated investigation of the role of polyamines in the results of 1H MRSI in detecting prostate cancer. The conventional metabolite ratio (tCho+PA+Cr)/Cit significantly discriminates between tumor and healthy tissue areas at 7 tesla, whereas the new ratio tCho/(Cit+PA+Cr) performs less in discriminating tumor from healthy tissue in the prostate in contrast to reports obtained from tissue samples.

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