The influence of polyamines on metabolite ratios in the prostate at 7 tesla
Mariska P Luttje 1 , Catalina S Arteaga de Castro 2 , Peter R Luijten 1 , Marco van Vulpen 1 , Uulke A van der Heide 2 , and Dennis WJ Klomp 1
Imaging Division, University Medical Center
Utrecht, Utrecht, Netherlands,
of Radiotherapy, the Netherlands Cancer Institute -
Antoni van Leeuwenhoek hospital, Amsterdam, Netherlands
In contrast to 1H MRSI at lower field strength, where
polyamine signals overlap with choline signals, our
results at 7 tesla demonstrate the ability to fit each
of the prostate metabolite resonances distinctively.
This facilitated investigation of the role of polyamines
in the results of 1H MRSI in detecting prostate cancer.
The conventional metabolite ratio (tCho+PA+Cr)/Cit
significantly discriminates between tumor and healthy
tissue areas at 7 tesla, whereas the new ratio
tCho/(Cit+PA+Cr) performs less in discriminating tumor
from healthy tissue in the prostate in contrast to
reports obtained from tissue samples.
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