Meeting Banner
Abstract #1189

Topographic Modifications of T1-Gd in Early Osteoarthritic Tibial Cartilage by MRI at Microscopic Resolution

Ji hyun Lee 1 , Farid Badar 2 , and Yang Xia 3,4

1 Oakland Univ, Rochester, Michigan, United States, 2 Oakland Univ, Michigan, United States, 3 Physics, Oakland University, Rochester, Michigan, United States, 4 Center for Biomedical Research, Oakland University, Michigan, United States

This study quantified the topographical and zonal changes of T1 in healthy and osteoarthritic tibial cartilage in canines. T1 of cartilage when soaked in gadolinium showed an increasing trend from the surface to deep cartilage. The zonal T1 values from the meniscus-covered area were significantly higher than those from the uncovered area for most sub-tissue zones (except the deepest tissue and bulk). The average T1 decreased with OA advance and the cartilage thickness increased at early osteoarthritic lesion. This study could help to design more effective protocols to detect the early lesions in the clinics.

This abstract and the presentation materials are available to members only; a login is required.

Join Here