Abstract #1190
Multiparametric MR Relaxometry for articular and epiphyseal cartilage during skeletal maturation in a goat model
Luning Wang 1 , Mikko J Nissi 2 , Ferenc Toth 3 , Cathy Carlson 3 , and Jutta Ellermann 1
1
Center for Magnetic Resonance Research,
University of Minnesota, Twin Cities, Minneapolis, MN,
United States,
2
Medical
Research Center Oulu, Oulu University Hospital and
University of Oulu, Finland,
3
University
of Minnesota, Twin Cities, Minneapolis, MN, United
States
In this study, established and novel MR relaxometry
methods are utilized in the developing skeleton to study
cartilage maturation. Quantitative Relaxation time
mapping, T1, T2, contineous wave (CW) T1ρ, adiabatic
T1ρ, and TRAFF, revealed consistently higher relaxation
times in articular compared to epiphyseal cartilage with
peak relaxation times occurring in both at about 3 weeks
of age. Multiparametric MR relaxometry serves as a
valuable noninvasive tool for monitoring changes in
cartilage during normal maturation in goats and may be
applied in the future to study developmental
abnormalities in both animals and human beings.
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