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Abstract #1190

Multiparametric MR Relaxometry for articular and epiphyseal cartilage during skeletal maturation in a goat model

Luning Wang 1 , Mikko J Nissi 2 , Ferenc Toth 3 , Cathy Carlson 3 , and Jutta Ellermann 1

1 Center for Magnetic Resonance Research, University of Minnesota, Twin Cities, Minneapolis, MN, United States, 2 Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Finland, 3 University of Minnesota, Twin Cities, Minneapolis, MN, United States

In this study, established and novel MR relaxometry methods are utilized in the developing skeleton to study cartilage maturation. Quantitative Relaxation time mapping, T1, T2, contineous wave (CW) T1ρ, adiabatic T1ρ, and TRAFF, revealed consistently higher relaxation times in articular compared to epiphyseal cartilage with peak relaxation times occurring in both at about 3 weeks of age. Multiparametric MR relaxometry serves as a valuable noninvasive tool for monitoring changes in cartilage during normal maturation in goats and may be applied in the future to study developmental abnormalities in both animals and human beings.

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