Abstract #1193

Reduction of magic angle effect for quantitative MRI of articular cartilage in vivo

Mikko Johannes Nissi ^1,2 , Victor Casula ^1,2 , Eveliina Lammentausta ^2,3 , Shalom Michaeli ⁴ , Silvia Mangia ⁴ , Edward Auerbach ⁴ , Jutta Ellermann ⁴ , and Miika T Nieminen ^1,3

¹ Department of Radiology, Institute of Diagnostics, University of Oulu, Oulu, Finland, ² Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland, ³ Department of Radiology, Oulu University Hospital, Oulu, Finland, ⁴ CMRR, Department of Radiology, University of Minnesota, Minneapolis, MN, United States

Magic angle effect is a major confounding factor in both quantitative and qualitative assessment of articular cartilage, as well as of other tissues. Recently, reduced magic angle dependence was demonstrated for adiabatic T ₁ relaxation time in articular cartilage. In this work, adiabatic T ₁ and T ₂ relaxation time constants of human knee articular cartilage were measured in vivo at 3 T. Adiabatic T ₁ relaxation time maps demonstrated reduced magic angle effect in cartilage regions at susceptible angles as compared to T ₂ relaxation time. Adiabatic T ₁ technique provides a promising alternative to T ₂ for the assessment of articular cartilage.

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