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Abstract #1192

Importance of Biexponential T2* and Partial Volume Effect Corrections on Quantification of Sodium Concentrations and Fixed Charge Density of Articular Cartilage with 23 Na-MRI at 7T

Lasse P. Rsnen 1 , Stefan Zbyn 2 , Miika T. Nieminen 3,4 , Eveliina Lammentausta 3 , Xeli Deligianni 5,6 , Oliver Bieri 5 , Siegfried Trattnig 2 , and Rami Korhonen 1

1 Department of Applied Physics, University of Eastern Finland, Kuopio, Finland, 2 MR Centre-High Field MR, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria, 3 Department of Diagnostic Radiology, Oulu University Hospital, Oulu, Finland, 4 Department of Radiology, University of Oulu, Oulu, Finland, 5 Division of Radiological Physics Department of Radiology, University of Basel Hospital, Basel, Switzerland, 6 Merian Iselin Klinik, Basel, Switzerland

The importance of the biexponential decay of the transverse relaxation of sodium ( 23 Na) and the signal attenuation due to partial volume effect (PVE) were investigated, while determining 23 Na concentration and FCD of the tibial and femoral cartilage tissues with MRI. The use of biexponential signal correction together with PVE increased the 23 Na concentrations up to +179%, thus also enabling the quantification of FCD of cartilage. The results suggest that biexponential signal decay and PVE can be notable even at 7T and relatively small resolution and should be considered when quantifying 23 Na content and FCD from 23 Na-MRI.

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