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Abstract #1220

Vertebral bone marrow fat content measured by MRI associated with lower bone mineral density: a human cadaver study

Miyuki Takasu 1 , Yuji Akiyama 1 , Ryuji Akita 1 , Kazushi Yokomachi 1 , Yoko Kaichi 1 , Shuji Date 1 , Masatoshi Honda 2 , and Kazuo Awai 1

1 Diagnostic Radiology, Hiroshima University Hospital, Hiroshima, Hiroshima, Japan, 2 Philips Electronics, Tokyo, Japan

Clinical studies using different methods including MRS to assess marrow fat have found a negative correlation with BMD. The present cadaveric study was conducted in order to validate the relationships among vertebral marrow fat, BMD, and bone strength. Values of fat fraction assessed with mDIXON correlated with those from 1H MRS. There was a negative correlation between marrow fat and tissue BMD. This relationship can also be assessed by the mDIXON technique. Further study is needed to assess the feasibility of using mDIXON for quantification of vertebral marrow fat in vivo.

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