Abstract #1220
Vertebral bone marrow fat content measured by MRI associated with lower bone mineral density: a human cadaver study
Miyuki Takasu 1 , Yuji Akiyama 1 , Ryuji Akita 1 , Kazushi Yokomachi 1 , Yoko Kaichi 1 , Shuji Date 1 , Masatoshi Honda 2 , and Kazuo Awai 1
1
Diagnostic Radiology, Hiroshima University
Hospital, Hiroshima, Hiroshima, Japan,
2
Philips
Electronics, Tokyo, Japan
Clinical studies using different methods including MRS
to assess marrow fat have found a negative correlation
with BMD. The present cadaveric study was conducted in
order to validate the relationships among vertebral
marrow fat, BMD, and bone strength. Values of fat
fraction assessed with mDIXON correlated with those from
1H MRS. There was a negative correlation between marrow
fat and tissue BMD. This relationship can also be
assessed by the mDIXON technique. Further study is
needed to assess the feasibility of using mDIXON for
quantification of vertebral marrow fat in vivo.
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