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Abstract #1221

Frequency dependant shear properties of bovine ex vivo intervertebral disc.

Delphine Perie 1 , Pierre-Francois Beauchemin 1 , Phil Bayly 2 , Joel R Garbow 2 , John Schmidt 2 , Ruth Okamoto 2 , and Farida Cheriet 1

1 Mechanical Engineering, Polytechnique Montreal, Montreal, Quebec, Canada, 2 Mechanical Engineering and Materials Science, Washington University in St. Louis, Saint Louis, Missouri, United States

Aging and degeneration have been shown to be associated with changes in intervertebral disc mechanical properties, generating interest in the use of mechanical properties to establish early biomarkers for the degenerative cascade. This study demonstrated that global mechanical characterization of the intervertebral disc, including both nucleus pulposus and annulus fibrosus, was possible with high frequency needle magnetic resonance elastography. The advantages and limitations of different approaches to the inversion problem in the intervertebral disc were also determined. The developed method could be adapted in vivo to assess the contribution of osmotic pressure to the mechanical behavior of the intervertebral disc.

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