Abstract #1228
MRI monitoring for muscular dystrophy mice treated with gene therapy
Joshua Park 1 , Jacqueline Wicki 2 , Sue Knoblaugh 3 , Jeffrey Chamberlain 2,4 , and Donghoon Lee 1
1
Radiology, University of Washington,
Seattle, WA, United States,
2
Neurology,
University of Washington, Seattle, WA, United States,
3
Fred
Hutchinson Cancer Research Center, Seattle, WA, United
States,
4
Biochemistry,
University of Washington, Seattle, WA, United States
Multi-parametric MRI was performed to monitor disease
progression and responses to adeno-associated viral
(AAV) vector-mediated gene therapy for mice with
muscular dystrophy. We quantified T2, magnetization
transfer ratio and apparent diffusion coefficients along
with 3 dimensional volume measurements for the
monitoring. Mice were imaged at 3 months of age for
pre-treatment and post-treatment at 8, 16 and 24 week
time points. Histopathology was also conducted for
tissues collected from the hindlimbs after the final
time point for comparison. T2 relaxation, alongside
diffusion and magnetization transfer effects provides
useful data towards the goal of non-invasively
monitoring the treatment of muscular dystrophy.
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