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Abstract #1228

MRI monitoring for muscular dystrophy mice treated with gene therapy

Joshua Park 1 , Jacqueline Wicki 2 , Sue Knoblaugh 3 , Jeffrey Chamberlain 2,4 , and Donghoon Lee 1

1 Radiology, University of Washington, Seattle, WA, United States, 2 Neurology, University of Washington, Seattle, WA, United States, 3 Fred Hutchinson Cancer Research Center, Seattle, WA, United States, 4 Biochemistry, University of Washington, Seattle, WA, United States

Multi-parametric MRI was performed to monitor disease progression and responses to adeno-associated viral (AAV) vector-mediated gene therapy for mice with muscular dystrophy. We quantified T2, magnetization transfer ratio and apparent diffusion coefficients along with 3 dimensional volume measurements for the monitoring. Mice were imaged at 3 months of age for pre-treatment and post-treatment at 8, 16 and 24 week time points. Histopathology was also conducted for tissues collected from the hindlimbs after the final time point for comparison. T2 relaxation, alongside diffusion and magnetization transfer effects provides useful data towards the goal of non-invasively monitoring the treatment of muscular dystrophy.

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