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Abstract #1229

Inter-echo time dependence of CPMG relaxation rate around capillaries in skeletal muscle tissue

Felix T Kurz 1 , Thomas Kampf 2 , Lukas R Buschle 3 , Sabine Heiland 4 , Martin Bendszus 4 , and Christian H Ziener 1,3

1 Heidelberg University, Heidelberg, BW, Germany, 2 University of Wuerzburg, Bavaria, Germany, 3 German Cancer Research Center, Heidelberg, BW, Germany, 4 Heidelberg University, BW, Germany

Capillary networks in muscle tissue are examined using Kroghs capillary model and it is shown that diffusion-dependent CPMG relaxation rates depend on microstructural parameters such as capillary radius, nuclear spin diffusion and regional blood volume fraction. The findings agree well with experimental data and can be used to quantify microstructural parameters that correlate with denervation- or age-related microcirculatory remodeling in skeletal muscle.

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