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Abstract #1237

Canine MRI for X-linked myotubular myopathy

Joshua Park 1 , Martin Childers 2 , and Donghoon Lee 1

1 Radiology, University of Washington, Seattle, WA, United States, 2 Rehabilitation Medicine, University of Washington, Seattle, WA, United States

Multi-parametric MRI was performed on a 3T MR human scanner to monitor disease progression and responses to adeno-associated viral (AAV) vector-medicated gene therapy for dogs with X-linked myotubular myopathy (XLMTM). We quantified T2 and apparent diffusion coefficients along with 3 dimensional volume measurements for the monitoring. Histopathology was also conducted for tissues biopsized from the hindlimbs after MRI for comparison. T2 relaxation, alongside diffusion effect provides useful data towards the goal of non-invasively monitoring the treatment of XLMTM. To our knowledge, this is the first MRI study to assess the disease and treatment responses for the canine model of XLMTM.

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