Abstract #1238
Quantitative Measurement of Blood Flow in Contracting Rat Muscle Using MR Angiography
Anne Tonson 1,2 , Jonathan Kasper 1,2 , Ronald A Meyer 3,4 , and Robert W Wiseman 2,3
1
Physiology Department, Michigan State
University, East Lansing, MI, United States,
2
Biomedical
Imaging Research Center, Michigan State University, East
Lansing, MI, United States,
3
Physiology and
Radiology Departments, Michigan State University, East
Lansing, MI, United States,
4
Biomedical
Imaging Research Center, East Lansing, MI, United States
This study aimed to investigate the effect of skeletal
muscle workload on local muscle blood flow and the
corresponding time-course of flow recovery in the rat
hindlimb using 2D_ PC-MRA measurements in the femoral
vein. The present results showed a significant increase
in flow from baseline in response to contraction
regardless of the intensity. The corresponding change
was lower for non- fatiguing stimulation (≤1Hz) compared
to fatiguing contraction (≥2Hz) for which we also
observed a reactive hyperemia. This study shows that
MRI-based regional blood flow measurement can be used
for the quantitative investigation of post-contraction
time-course of flow recovery
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