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Abstract #1249

Assessment of resting skeletal muscle alkaline Pi pool and PDE concentration by 31 P-MRS at 7T and its relation to mitochondrial capacity and Pi-to-ATP exchange rate

Ladislav Valkovic 1,2 , Marjeta Tuek Jelenc 1 , Barbara Ukropcov 3,4 , Wolfgang Bogner 1 , Matej Vajda 5 , Thomas Heckmann 6 , Miroslav Bal 3 , Marek Chmelk 1 , Ivan Frollo 2 , Norbert Bachl 6 , Jozef Ukropec 3 , Siegfried Trattnig 1 , and Martin Krk 1,7

1 High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, 2 Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, 3 Obesity section, Diabetes and Metabolic Disease Laboratory, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia, 4 Institute of Pathophysiology, Faculty of Medicine, Commenius University, Bratislava, Slovakia, 5 Faculty of Physical Education and Sport, Commenius University, Bratislava, Slovakia, 6 Department of Sports and Physiological Performance, University of Vienna, Vienna, Austria, 7 Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria

This study aimed to assess the interrelations between measures derived from 31 P-MRS in quadriceps femoris muscle at 7T in three physiologically different subject groups. Resting state alkaline Pi (Pi 2 /Pi 1 ), phosphodiester concentration ([PDE]), Pi-to-ATP exchange rate constant assessed by saturation transfer and maximal mitochondrial capacity assessed by dynamic 31 P-MRS during recovery from exercise were analyzed. Our results show that resting measurements of Pi 2 /Pi 1 and [PDE] may provide an alternative biomarker of skeletal muscle mitochondrial capacity, complementing or overcoming the necessity of complex experimental set-up for dynamic examinations.

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