Abstract #1249
Assessment of resting skeletal muscle alkaline Pi pool and PDE concentration by 31 P-MRS at 7T and its relation to mitochondrial capacity and Pi-to-ATP exchange rate
Ladislav Valkovic 1,2 , Marjeta Tuek Jelenc 1 , Barbara Ukropcov 3,4 , Wolfgang Bogner 1 , Matej Vajda 5 , Thomas Heckmann 6 , Miroslav Bal 3 , Marek Chmelk 1 , Ivan Frollo 2 , Norbert Bachl 6 , Jozef Ukropec 3 , Siegfried Trattnig 1 , and Martin Krk 1,7
1
High Field MR Centre, Department of
Biomedical Imaging and Image-guided Therapy, Medical
University of Vienna, Vienna, Austria,
2
Department
of Imaging Methods, Institute of Measurement Science,
Slovak Academy of Sciences, Bratislava, Slovakia,
3
Obesity
section, Diabetes and Metabolic Disease Laboratory,
Institute of Experimental Endocrinology, Slovak Academy
of Sciences, Bratislava, Slovakia,
4
Institute
of Pathophysiology, Faculty of Medicine, Commenius
University, Bratislava, Slovakia,
5
Faculty
of Physical Education and Sport, Commenius University,
Bratislava, Slovakia,
6
Department
of Sports and Physiological Performance, University of
Vienna, Vienna, Austria,
7
Division
of Endocrinology and Metabolism, Department of Internal
Medicine III, Medical University of Vienna, Vienna,
Austria
This study aimed to assess the interrelations between
measures derived from
31
P-MRS
in quadriceps femoris muscle at 7T in three
physiologically different subject groups. Resting state
alkaline Pi (Pi
2
/Pi
1
),
phosphodiester concentration ([PDE]), Pi-to-ATP exchange
rate constant assessed by saturation transfer and
maximal mitochondrial capacity assessed by dynamic
31
P-MRS
during recovery from exercise were analyzed. Our results
show that resting measurements of Pi
2
/Pi
1
and
[PDE] may provide an alternative biomarker of skeletal
muscle mitochondrial capacity, complementing or
overcoming the necessity of complex experimental set-up
for dynamic examinations.
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